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Yoshida, Fumiyo*; Matsumura, Akira*; Yamamoto, Tetsuya*; Kumada, Hiroaki; Nakai, Kei*
Cancer Letters, 215(1), p.61 - 67, 2004/11
Times Cited Count:13 Percentile:22.4(Oncology)Sodium borocaptate (BSH) is widely used for Boron Neutron Capture Therapy (BNCT) of brain tumors. However, the mechanism of uptake by the tumor remains unclear. We investigated the sulfhydryl moiety of this compound. Down regulation of glutathione (GSH) by buthionine sulfoximine (BSO) in cultured cells resulted in increase of BSH uptake (7.9 %-36.5 %) compared to control group and subsequently cytocidal effect of neutron irradiation also increased. The radiation damage by -ray irradiation was suppressed by enhancement of BSH uptake. These findings suggested that modulation of GSH induce enhancement effect of B(n,) reaction and protective effect of secondary -ray in BNCT.
*; *; *
JAERI-Research 94-024, 40 Pages, 1994/10
no abstracts in English
*
JAERI-M 84-239, 59 Pages, 1985/01
no abstracts in English
;
JAERI-M 84-224, 69 Pages, 1985/01
no abstracts in English
*
JAERI-M 83-199, 83 Pages, 1983/11
no abstracts in English
Int.J.Appl.Radiat.Isot., 34(3), p.559 - 564, 1983/00
no abstracts in English
JAERI-M 82-192, 95 Pages, 1982/12
no abstracts in English
*
JAERI-M 9214, 146 Pages, 1980/11
no abstracts in English
; *
J.Ferment.Technol., 58(4), p.363 - 366, 1980/00
no abstracts in English
; *
Japanese Journal of Applied Physics, 19(7), p.1241 - 1245, 1980/00
Times Cited Count:11 Percentile:50.71(Physics, Applied)no abstracts in English
*
JAERI-M 8569, 146 Pages, 1979/11
no abstracts in English
; Kuriyama, Isamu
J.Mater.Sci., 14(7), p.1733 - 1743, 1979/00
Times Cited Count:13no abstracts in English
Sasuga, Tsuneo
JAERI-M 7485, 93 Pages, 1978/01
no abstracts in English
*
JAERI-M 7355, 85 Pages, 1977/10
no abstracts in English
Arakawa, Kazuo; Hayakawa, Naohiro; Kuriyama, Isamu
JAERI-M 7244, 29 Pages, 1977/09
no abstracts in English
Nuclear Instruments and Methods, 146, p.599 - 600, 1977/00
no abstracts in English
*; ; *; *
Hakko Kogaku Zasshi, 53(2), p.84 - 91, 1975/02
no abstracts in English
Saeki, Masakatsu; *; Tachikawa, Enzo
Int.J.Appl.Radiat.Isot., 25(9), p.407 - 414, 1974/09
Times Cited Count:8no abstracts in English
Tachikawa, Enzo; Tsuchihashi, Genichi
Bulletin of the Chemical Society of Japan, 34(6), p.770 - 774, 1961/00
Times Cited Count:3no abstracts in English